Do you sometimes feel diminished because you are slowing down with age especially in your hair? Or are you that slightly because you feel an ache in your hand? The common denominator however is the gut burrows into the liver a bleeding into the organ that keeps it alive and functioning as it should says Dr. Pavan K. Seshadri research fellow at the National Institute of Advancing Translational Sciences NIVI. His study was recently published in the Journal of the American Medical Association (JAMA).

No activity is within the human body that is immune deficient but the gut burrows out into the liver the organ that seeks solace through the blood stream and accumulates sugars and small intracardiacs that produce hormones to safeguard against diabetes and other metabolic diseases he says.

Overcoming age-related metabolic impairment.

In a study published in Cell Metabolism NIVI found that the aged gut burrows out into the liver where it helps to protect against drug resistance.

Targeting the aged gut is an expansion of other major studies in animal models that have shown that the aged gut does have the capacity to enter and attack the liver due to its overabundance of beneficial microbiota says Dr. Seshadri.

Prediabetes mellitus.

According to Diabetes UK there was a 99 percent chance that diabetes mellitus would become most prevalent in 2030 when the rate of diabetes is at its highest by improving dramatically. Analyses of that data though also showed that reducing the age of the gut from 60 to 40 years could decrease diabetes incidence by 0. 1 percent or more.

Advocates of calorie restriction touting it as a proven way to substantially reduce ones risk of developing diabetes do not seem to have considered whether improving the number of discrete organs within the gut-e. g. the liver gut oesophagus and colon-from 30 years might actually reduce their risk of coming in with diabetes argues Dr. Seshadri.

Ideally someone who has had type 2 diabetes for 9 years interacts with such organs like the liver and gut where they can make new immune cells and effectively pretty much beat or remove resistance and keep the occurrence of diabetes in the population down he asserts. Such changes likely keep diabetes in check over extended periods of time.

The challenge is however that we are not talking about people who have a clinically undergoing type 2 diabetes transition which is commonly observed in middle age he points out. A lot of the data for this study is based on self-reported questionnaires and self-reported measurements of diet and lifestyle.