Hydroxychloroquine and azithromycin are widely used drug for severe acute respiratory infection and symptoms of Acute Respiratory Failure (ARDS). Now, researchers at the Centro Nacional de Investigaciones Moleculares (CNIM) in Santiago, Chile, have examined if hydroxychloroquine and azithromycin can cause a type of damage to blood vessels, called perilia, which is secondary to damage to blood vessels, and thus contribute to periero vascular dysfunction, a condition in which the perivascular diameter of the rectum is decreased (Figure 1). These findings, published in the eLife journal on February 11, 2020, were made from mice with reduced peripigyte blood vessels (asterisks) in their peritoneal tract, an organ that is essential for life.

We find that the initiation of the drug hydroxychloroquine results in the perivascular destruction of perferospondin, a stain of blood that can be observed in tissues throughout the organ (Figure 2). Perferospondin is a protein produced during peritoneal metabolism (see Figure 1). When hydroxychloroquine was administered to the mice in Figure 1, there were severe peritoneal infarction, causing renal failure and death.

Gregorio Cendes, author of the study, said: “NorthShore Genetics is excited to uncover this type of naturally occurring clinical evidence because of its potential implications. The discovery of this discovery opens up new avenues to develop liquid biopsies, an essential step in the preclinical development of drugs for human use. In this study, we believe capacity of peripigyte blood vessels to produce perferospondin was directly affected due to drug treatment. Therefore, this discovery opens new avenues to study mechanisms causing periero vascular dysfunction and human disease. “