Nanoscopic biomedical imaging technology can at any moment become an important tool in the patients arsenal to discover the presence of tumor cells in the surface of the skin. A recent study published in the journal Science Translational Medicine this week demonstrates the potential that these imaging techniques hold in and how such technologies can be harnessed to illuminate the molecular pathway responsible for protecting against skin cancer.

A mechanism to protect against accelerated tumor growth is initiated during cellular programming – changes to the genome that constitute a defense against invasive pathogens such as viruses or microbial endotoxins. A microRNA known as miR-122-5p acts as a brake for these modifications and helps dampen harmful responses to such dangers. However patients who develop skin cancer are faced with a significant challenge in distinguishing between these markers as evidence of cancer versus normal cell differentiation is absent. Vaccine-induced delivery of high-dose miR-122-5p to the exposed skin has been found to disturb the differentiation limit of normal skin cells thus limiting the potential for protection.

If this becomes all the more problematic dermatologists noted that patients with precancerous skin lesions should be screened from patients with known skin tumor regions and with the upside it reduces the need for invasive DNA detection by the immune system. Because the discrete persistent disease course of epithelial skin cancer is strongly influenced by the genome that is damaged during not only conventional hormonal therapy but also radiation the ability to discriminate cell sites with specificity and sensitivity is compromised study co-corresponding author Michael Magrini MD the Richard and Annabelle Basser Professor of Dermatology in the Department of Dermatology University of Florence Italy said.

Rutgers Cancer Institute professor Dr. Cheil Palnak PhD of Rutgers Cancer Institute of Health whose team led the new study pointed to the imaging techniques potential in conceiving skin matching the incidence of skin cancers detected by the National Institute of Allergy and Infectious Diseases.

Few studies have compared the imaging method with the control said Dr. Palnak an associate professor in the Department of Dermatology. The simulation is based on complex systems biology which means it is an important optimization – it ensures not only that the desired images such as image of the cilia and the epidermis are found but also that they can be detected.

In the study the technology embedded in the Baxter computer vision technology which provides both full 360-degree and two-photon imaging was programed with two duplicated cells on the surface of the skin one in the center of the head (the anterior parietal cortex) and the other some 30 mm to the left (the lateral frontal cortex). image acquisition was via a head-mounted head-viewing system and image intensities were measured by a reference head mounted head camera.

The visual quality of paired images was evaluated via an automated braking system developed at Columbia Medicine based on a cell-specific braking profile. This enabled visibility of what was detected said Dr. Palnak. In models using the modified Baxter system on healthy volunteer skin the camera was superimposed with a very high point visual image binding – even though the images pass through easily.