Karolinska Institutet researchers have identified a gene involved in the development of several types of cancer in mice. The results are important for researchers trying to develop new vaccines to combat such cancers. The findings are presented in the scientific journal Cell Reports.

Many diseases such as cancer arise through the interaction of genes responsible for regulating gene expression. One such gene known as STAT3 plays a vital role in the immune system regulating the immune system to protect against microorganisms found in the body. One group of mutations occurring in certain patients are associated with a deficiency in this gene.

Scientists have begun to look for more and more genes that fold STAT3 in a similar way to how cancer cells favour certain cancer-promoting genes. Scientists working with STAT3 in these studies thus far have found three new genes involved in STAT3s activity. The new analysis now corroborates the characterization of the gene by researchers at Karolinska Institutet which showed that the genes expression is affected in malignant and non-malignant forms of breast prostate and colorectal cancer.

Uncovering the role of STAT3.

Scientists have thus far uncovered the potential significance of specific genes involved in STAT3s activity. The results are described in the scientific journal Cell Reports.

One of the researchers behind the study Associate Professor Ole Gustafsson at the Department of Biomedical Sciences at Karolinska Institutet first identified the association between certain abnormal genes and STAT3. This information is important for the information-driven research of this field which is necessary to understand how the cancer develops and how it can be stopped.

The sequencing of a portion of DNA of single individuals with a particular variant of the gene resulted in identification of a hypermutation of STAT3-related genes. The researchers also learned that the so-called miR-1000B protein is the most important protein involved in STAT3s activity.