The powerful new immunotherapy approach to treating many types of cancer is undergoing clinical trials at UW Medicine and will soon be available for people living with immune systems damaged by certain childhood diseases.

The breakthrough gives survival chances sky-high for people with spastic lymphoma bone marrow cancer and hypokalemic acidosis a type of medical emergency that results in too much acidic blood.

Our technique is uniquely effective and also conserved said Paul Hermelin MD the Nanci Heart Tumor Foundation professor of neurology and director of UW Medicines Division of Pediatrics. It allows us to treat patients with multiple types of pediatric infectious and chronic conditions much more effectively.

Hermelin has a long history of successfully using the lab-grown lymph nodes and tumor cells of patients with serious and difficult-to-treat cancer including a quadruple-negative breast cancer that he successfully treated at UW Medical with MDA-MB-231 a drug target in the blood-marrow cancer mesenchymal stem cells that can yield highly effective gene-targeted DSS cells which become lymphocytes and fight incidences of blood cancers.

Glioblastoma the most common form of brain cancer is treated with the most powerful type of radiation known as gamma irradiation but is typically not curable without two or more doses. The UW Ryder Trauma and Insurgizing Treatment Center has pioneered an improved three-drug combination therapy called KoiVax. Transcutaneous gamma irradiation includes a treatment known as UVB which causes eye damage but is rarely used in glioblastoma.

Labour for the BioTek Nexx viscoabron is being used in the UW Medical Multiple myeloma clinic with current treatment. The application for conventional radiation and KoiVax are in development as well.

We have collaborated with some of the best local tumor specialists in the state and have helped achieve our goal of being able to treat children and adolescents with glioblastoma said Dr. Michael Burke MD PhD professor of radiology at UW Medicine.

He is leading a clinical trial that will enroll 576 people for a period of five years.

New treatment methods.

New findings by Hermelins lab show that KoiVax is efficient in treating the glioblastoma and has no harmful side effects. In a test with mice this genome editing technology was involved in eradicating the cancer in some mice while not causing any toxicity to others. Optimal safety in a clinical trial is very important since the therapy can be expanded into use for an additional 15 years or more if required.