In what is believed to be the first experiment with mice that share human counterparts Vanderbilt University researchers have demonstrated the possibility that the actin cytoskeleton may be modified by endocannabinoids. When the cells are exposed to endocannabinoids the structure of the cytoskeleton changes highlighting the potential of endocannabinoids as potential drug targets for conditions such as Parkinsons disease.

A new meta-analysis of an existing study recently published in the Proceedings of the National Academy of Sciences suggests the introduction of an experimental model that mimics human diseases and that also shows the dramatic effects endocannabinoids have on epithelial cell states characteristic of many diseases.

Our data demonstrate that the actin cytoskeleton may be modified by endocannabinoids and therefore may not mimic human disease in patients.

Ruthann Rudebusch M. D. Benjamin Levan Jr. Professor of Cell Biology and Biology Physiology and Frederick L. Stijles Professor of Biology Systems Pharmacology Translational Therapeutics Vanderbilt University School of Medicine.