Scientists have used location-tracking technology to predict the odds that patients will develop skin cancer in the future according to a study published today in Nature Clinical Cancer Research.
Each patient in the study benefitted from a unique combination of two types of node cell death known as the K-cancer and lymphothrosarcoma. K-cell death is a result of defective stemprogenitor cells dying before they have a chance to divide leaving behind only cancer cells. Lymphothrosarcoma is caused by uncontrolled hyperactivation of lymphocytes cells that reside under the skin and are capable of doing everything required for survival.
Researchers created a computer model to estimate the likelihood that a patient will develop lymphothrosarcoma compared with their bone marrow status at age 80 and predicted the odds in terms of skin cancer separately.
Weve known for some time that patients with low levels of L (leukemic) cells are more susceptible to developing skin cancer but we didnt know which areas of the body L cells could kill said the studys lead author Silvia Santazzo a professor at the National Cancer Center of Milan Medical School in Italy. Now we have a tool that could be used to estimate patients risk of developing certain types of skin cancer including skin cancers diagnosed in women.
A democratic model:
Researchers added skin cancer cases to the study by estimating the overall number of patients involved in the study as well as the number of deaths from different types of skin cancer.
Seven patients with elevated levels of L (leukemic) cells died while the remaining three deaths were not particularly associated with lymphothrosarcoma.
The researchers hypothesized that high levels of L cells in the epidermis could cause smooth muscle cells to die away and leave behind a component of the skin that suffers a protective feature called adipogenesis.