Fractured skin papillomatoses (FPS) – or bloody toenails – are common in newborns. Despite the ease and speed of diagnosis, treating them is complicated for a number of reasons, including the retention of blood cells, common for treating burns injuries. Scientists have known for their efforts to treat FPS for several years, but at a relatively large size and molecular complexity, their approach is still limited. In a new study, researchers at the University of Copenhagen have not only developed a new treatment approach but also reported a way that it may be used to treat older FPS patients.

We are hoping that our technique can help in helping to treat older FPS patients, because in the end FPS patients may benefit from a new treatment, because we have shown that the therapeutic agents we developed can make FPS patients heal much faster than previously thought. We expect that the therapeutic approaches we used would also play a role in the discovery of new drugs that can be used to treat FPS patients with painful conditions. “

Søren Skoog Rasmussen, Associate Prof. at the Department of Medical Biochemistry and Biophysics of the University of Copenhagen.

The results published in Nature Chemical Biology show how the research team has succeeded in developing a “preservative bond” with a widely used chemolytic enzyme, RhoA-PTP (Reagin oncogene protein), promising to help healing skin cells. The chemistry of RhoA-PTP is effective at breaking down fats that stick to skin cells, dusty behind unsightly wounds, and also contributes to the growth of stem cells.