Lysosomes are organelles known for recycling raw materials into different structures of the cell. They are particularly important for protein synthesis and biosynthesis but their use can also be harmful for nutrient utilization. In recent years several studies have shown the role of keratinocyte membranes (LNs) as a major pathogenic factor in the LNs. To determine this connection researchers from the LEGOS Laboratory of Biosystems Innovation and Nanomedicine at the Medical University of Denmark focused on the interaction between LNs and keratinocyte membranes. Our results show that LNs can bind with keratinocyte membranes and activate the so-called proteinaceous barrier says Nina Lindkvist Gamberg Rasmussen a Ph. D. candidate in the Legos laboratory and the first author of the study. If this is confirmed in subsequent studies it can be suggested as a biological explanation for potential adverse outcomes associated with LNs use in the kidney. According to the researchers the effects on regulating blood glucose and insulin levels depend on the structure of the LN. One important type of cell receptors are proteinaceous platelets. The researchers also did not find a connection between the removal of cellular proteinaceous platelets and the development of diabetes or obesity. Our findings show the importance of studying cell pathways in other cell types says Nina Lindkvist Gamberg Rasmussen. We hope that our work will bring us closer to the answers for these important questions.