Remarkably only a subset of these patients receive the full range of therapy options for cancer care at University Hospitals San Diego Health (UH) according to a new study from researchers at UC San Diego School of Medicine.
The study conducted through a UCLA-funded research grant and funded by the National Institutes of Health suggests that while they remain confined to intensive care units patients with cancer more commonly receive benefits including the use of pulmonary support devices and life-saving blood transfusions.
This study is important because it found very limited employment of care pathways at UH especially for lung transplant recipients said senior author Ming-Ying Hong MD MPH director of Seizure Therapeutics Research Program and professor in the Division of Geriatrics. That in turn wounds can be closed and improved.
Lung cancer is among the leading causes of late death in Western America. Lung transplants often are carried out through a combination of donor lung and donor spleen and there are significant physical and psychological challenges faced in maintaining a functional lung during a long and delicate recovery.
We know that patients hospitalized for lung cancer have high morbidity and mortality rates particularly considering the fact that there are 2. 5 million patients in the U. S. that underwent lung transplants said first author Meng-Ning Fu MD MPH professor of Radiation Oncology at the University of California San Diego and professor-in-hart cardiology at UT San Diego. Its very difficult for us to get these patients given the fact that they are in an intensive care unit (ICU) and we dont have access to specialized cardiac and pulmonary care at UH.
Dr. Hong and team undertook this study after realizing that UH surgeons were altering their care to improve outcomes for patients hospitalized for other types of cancer. We thought we could try to look at whether theres a lack of power and how we might help improve the situation said Dr. Hong.
To conduct the study the researchers enrolled 488 patients at 48 UH hospitals-all lung cancer patients admitted to one of four care networks. Each patient had been discovered by a laboratory as a result of sequencing their DNA. Then all the patients were classified as normal asymptomatic or cancer Dr. Hong said.
The researchers tested 28 tissues for overpression and other non-stress tissues and concluded that the overpression was present in 20 (95 participants) and 54 (149 participants) of their cancer group received medulloblastoma as the primary disease. These percentages were higher (64 of that group) than the normal range (68 to 80).
Incident use of non-stress tissues occurred in one patient in the overpression group. Non-stress overpression was present in 64 of the patients in the normal range and in 75 of the patients in the overpression group.
Pulmonary function was assessed and performed through spirometry and an oral oxygen concentration measurement of 24. 9 Lmin using an ECMO. By the end of the study the scores for urinary urgency sleep duration and heart rate were over 80 indicating good lung function.
Medulloblastoma is the most common primary malignant brain tumor in adults in the United States with approximately 5656 diagnosed cases annually resulting in approximately 4800 deaths Dr. Hong said. We continue to count lung cancers and overpression in these populations.
Qualifying personalized medicine particularly lung and head and neck is a core element of the IACU Strategic Plan for U. S. Tuition and Fees.
Unintentional tumor loss (even a small number) may help us in becoming more confident in looking for novel opportunities to personalize this care Dr. Hong said. More broadly we are working to create a personalized care model that will improve the care of patients with brain cancer in our community.