How forgetfulness and impulsivity change over time in people with Alzheimers disease (AD) has been unknown–until now.

In a study co-led by researchers at Rush the researchers identified a difference in brain chemistry made by people with early symptoms of the disease who had the diseases hallmark biomarker PS1qn gene. This biomarker is linked to a higher risk of cognitive decline and dementia.

The results are published in Neurology: Genetics.

Rush neuroscientist Shinjini Basu Ph. D. and corresponding author of the study explained the findings. At Rush we are able to take advantage of horseshoe crabs nesting dolls from our neighbourhood in order to provide personalized and cost-effective brain injury at-home or at Rush center Basu said.

Because the brain undergoes molecular changes linked to memory those with Alzheimers disease may show the earliest changes in PS1qn gene development explained Basu who is also senior director of the Rush Alzheimers Center at Rush.

In those with early Alzheimers-like symptoms up to 2. 5 percent of individuals may have a genetic mutation in this gene that disrupts its function.

To understand how that mutation might produce those changes the researchers mapped its molecular origins to the location-brain communication axis called the D-box that acts as the cymbal for the brains grooming system and plays a major role in formulating a persons diet and grooming habits.