Neurons in the body channels signals to repair or replace lost muscle mass but a new study from the Max Planck Institute shows that doing so in the desired position stimulates sustained and sustained weight losses confirming the value of targeting molecular mechanisms linked to body function. In this research mice with congenital bilateral undernutrition lost significant amounts of lean body mass after a short bout of weight-lifting. To see whether such losses are sustained during a meal mice fed a high-protein diet over an extended period lost substantial amounts of post-meal weight. This result was achieved at 36 weeks of age in caloric restriction indicating that some peripheral mechanisms- including the release of leptin GLP-1 and insulin – regulating feeding and feeding behavior are essential mechanisms to maintain sustained weight losses.

The work published in the journal Cell Reports is led by Professor Markus Ploner group leader at the University of Heidelberg. It was conducted in collaboration with researchers from the University of Bern the Medical University of Innsbruck Karolinska Institutet and the University Hospital of Bern.

In healthy humans the sequence of muscle development from a normative to a congenital position can be expressed as a continuous repetitive action: The older one stands the greater will be the weight loss. In patients with congenital bilateral undernutrition this sequence is augmented through prolonged feeding of high-protein diets. With diets involving protein we have to make up for the lost muscle mass by increasing levels of the hormone leptin which can inhibit metabolism explains Ploner. Lower body weight can be achieved and sustained in the desired place by substantial calorie restriction. High protein diets containing protein and fat content B vitamins and micronutrients affect energy balance. The current study demonstrates that a design series of concentrial exercise bouts (SINGLES) over a relatively short period of time (12 weeks on either a high or low protein diet) can sustain muscle gains in the desired position for about 6 weeks in mice bearing both congenital bilateral undernutrition and normal weight. This suggests that SINGLES can be a stable reliable and specific laboratory-based set-up for humans with congenital bilateral undernutrition explains Ploner.

This discovery means that animals weight and muscle energy expenditure can be accurately monitored in the same particular position. Its a novelty finding that actually opens the door to a new technology which could stimulate and sustain sustained calorie restriction in the desired extreme continues Pater. By optimizing where and when in the cycle of SINGLES we may be able to achieve sustained calorie restriction in individuals with congenital bilateral undernutrition for up to several years.