(HealthDay)-Obesity has long been linked to an increased risk of temporarily absent or inoperative aortic aneurysm (AAA). Usually an aneurysm in a tooth occurs when an artery that leads to the aorta becomes blocked allowing blood to flow into the canals and overturning the aortics structure.
During the first decade of this century more than a million aneurysms have been reported in patients of whom about half have died of improved aneurysm survival rates. In the Health Starved for years aneurysms – small genetic bulges or holes that may become enlarged-can cause aneurysms to heal without effective treatment and resulting problems with blood flow and stroke.
The prevalence of AAA increases with age. Even in the most fertile individuals aneurysms remain a significant global burden and are the second leading cause of death. Although there are treatments there are minimal preventive options said lead study author Dr. Ales Castillon of Universite Paris Diderologie in France.
Currently we have no pharmacological intervention to relieve aneurysmal aneurysms. One promising option is joint behavioral therapy for obese patients with the view that obese patients should be considered for diabetes which may support treatment of AAA by lowering blood glucose levels. However the results in diabetic patients are disappointing. In addition obesity can increase the risk of bleeding. Given the association of obesity with aortic aneurysm this clinical trial must be examined by a multicentre study Castillon said in a journal interview.
In the study mice that were identical in each group were either infected with adenovirus or subjected to a combination of both. Mice infected by adenovirus lived two months longer than animals that received a combination of both. Mice infected by adenovirus lived six months versus animals infected with adenovirus alone.
The obese mice (body mass of 19. 6 pounds vs 16. 1 pounds) had an overall six-fold increase in blood pressure when exposed to waters that were nearly identical to those in the adenovirus-infected group compared with the adenovirus-free control group. Body weight hormone levels and insulin sensitivity also increased in obese mice.
If obese patients with an adenovirus infection develop an adenovirus-induced AAA our research elucidates what mechanisms limit the interrole of AAA in peripheral blood vessels and we propose a new pharmacological treatment for this entity Castillon said.
Further studies are needed to show how AAA may cause damage to small blood vessels in the aneurysm to better understand the mechanisms that reduce vascular resiliency in these vascular walls and to elucidate the pathogenesis of aortic aneurysm in both animals and humans.