A novel approach to maintaining heart function with major abnormalities in a process that helps the heart adapt to changes in blood pressure and blood sugar levels was recently shown in a study by researchers from the Institute of Biomedical Engineering UCSC-CSIC.

Researchers have developed a novel ground-breaking carbon-based biomaterial to enhance the regeneration of the heart muscle by repressing adverse conditions causing it to weakly regenerate.

The study published in the journal Advanced Materials on the basis of which the research team headed by Prof. Nelson T. Chen, of the Department of Biomedical Engineering UCSC-CSIC, delineates the use of graphene oxide, a material that is better known for its soft and light properties, for the application of the protocol developed in this study.

Our method is based on the concept of reprogramming natural materials that have endured working without having to change for a long period of time.

This occurs when the materials that carry a biological function can be quickly reworking and adapted to suit a certain trait or condition, providing a hybrid device that can perform both biological and synthetic functions.

In this case the company Graphene Portal Scientific Project, which has studied graphene for more than two decades, and solved many complex problems, have adopted a novel approach in creating in-vivo and 2-D fields that were very close to the human body.

In this case we’ve combined the use of the materials that carry biological functions in three different body regions and applied this paradigm to improve communication between different regions of the human body.

We’re grateful to be able to collaborate with the company Graphene Portal, which has helped us develop a highly effective adaptation medium to transport biological signal and control regeneration in the heart.

Developing a novel therapeutic capability with such a new material can act as a benchmark for the advancement of the field.

In the laboratory in the UCSC-CSIC, the team using a variety of different methods were able to successfully adapt cisplatin, a natural ligand, to be effective as a novel pump synapton for timing the activity of the biological signals.

Cisplatin is a specific ionic compound whose shape is perceived to soft the tissues of the body by the heart and is therefore easily adapted to make it effectively a cardiac polymer.

We have developed a process that has incorporated a number of unique features relevant to both the human body and magical solutions involving the use of natural materials that are chemically and physiologically friendly to the human body.

Excess enzyme activity can result in heart muscle cells shrinking and compromising its ability to recover.

The aim of this study was to develop a simple and effective solution for impaired regeneration of the heart; and eventually, will be to expand its application beyond cardiac applications.

The motivation to use carbon for the development of biomimetic materials stems from the widespread use of carbon-based biological components such as food, electronics and we elect windows.

We think that naturally occurring carbon is a promising material for the solution field and global practice has exploited it as biosimilar substitute materials for engineered applications.

We believe that the transition from a fossil energy to environmental, and this idea is not only of great relevance in energy production but also for renewable energy and everyday consumer products.

We do hope that our hope for tomorrow’s use of biomimetic materials on a large scale could be the spark that quells their use”

Gerald Jordan, Co-Director, in Charge of the Division of Biomedical Engineering.

Graphene Portal is the latest in a series of milestones on the concept and implementation of biosimilars, an emerging class of materials that seek to use the carbon in human body and animal tissues for biomedical applications.